Peran Potensial Farmasis dalam Optimalisasi Terapi Pasien Long COVID-19: Tinjauan Literatur
DOI:
https://doi.org/10.58222/juvokes.v4i2.1407Kata Kunci:
MCH Book; Behavior; Complications; PregnancyAbstrak
Long COVID-19 merupakan sindrom pasca infeksi akut SARS-CoV-2 yang ditandai dengan gejala yang menetap selama berminggu-minggu atau bahkan berbulan-bulan setelah fase infeksi akut berakhir. Gejala yang umum meliputi kelelahan kronis, gangguan tidur, nyeri otot atau sendi, gangguan pernapasan, serta disfungsi kognitif seperti kesulitan berkonsentrasi dan kabut otak. Kondisi ini memberikan tantangan baru dalam sistem pelayanan kesehatan, terutama dalam aspek manajemen jangka panjang. Meskipun demikian, peran farmasis klinis dalam tatalaksana pasien Long COVID-19 masih belum banyak dieksplorasi secara sistematis dalam berbagai studi. Artikel ini bertujuan untuk meninjau peran strategis farmasis dalam pemantauan farmakoterapi, pemberian edukasi kepada pasien, serta keterlibatan dalam tim kolaboratif interprofesional guna meningkatkan luaran klinis dan kualitas hidup pasien. Metode narrative review digunakan dengan menelaah berbagai literatur ilmiah dari tahun 2020 hingga 2024. Berdasarkan hasil tinjauan, keterlibatan farmasis terbukti berkontribusi terhadap pengurangan efek samping obat, peningkatan kepatuhan pasien terhadap regimen terapi, serta mendukung proses rehabilitasi secara menyeluruh. Dengan demikian, peran farmasis menjadi semakin penting dan perlu diintegrasikan dalam sistem layanan kesehatan untuk mendukung pemulihan pasien Long COVID-19 secara berkelanjutan.
Referensi
Al-Aly, Z., Davis, H., McCorkell, L., Soares, L., Wulf-Hanson, S., Iwasaki, A., & Topol, E. J. (2024). Long COVID science, research and policy. Nature Medicine, 30(8), 2148–2164. https://doi.org/10.1038/S41591-024-03173-6;SUBJMETA=250,2514,255,326,4130,596,631,692,699;KWRD=SARS-COV-2,VIRAL+INFECTION
Ceban, F., Ling, S., Lui, L. M. W., Lee, Y., Gill, H., Teopiz, K. M., Rodrigues, N. B., Subramaniapillai, M., Di Vincenzo, J. D., Cao, B., Lin, K., Mansur, R. B., Ho, R. C., Rosenblat, J. D., Miskowiak, K. W., Vinberg, M., Maletic, V., & McIntyre, R. S. (2022). Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis. Brain, Behavior, and Immunity, 101, 93–135. https://doi.org/10.1016/J.BBI.2021.12.020
Cezar Ambrósio, G., Dal Paz, K., de Souza, V. A. M., Discacciatii, M. G., & Campa, A. (2024). Impact of the COVID-19 Pandemic on Pharmacist Interventions: A Retrospective Study with Inpatients in a University Hospital. Canadian Journal of Hospital Pharmacy, 77(3). https://doi.org/10.4212/CJHP.3514,
Fernández-De-Las-Peñas, C., Navarro-Santana, M., Plaza-Manzano, G., Palacios-Ceña, D., & Arendt-Nielsen, L. (2022). Time course prevalence of post-COVID pain symptoms of musculoskeletal origin in patients who had survived severe acute respiratory syndrome coronavirus 2 infection: A systematic review and meta-analysis. Pain, 163(7), 1220–1231. https://doi.org/10.1097/J.PAIN.0000000000002496
Guzmán Cordero, C., Sáez-Torres de Vicente, M., Jiménez Espinosa, Á., & Gago Sánchez, A. I. (2025). Pharmacist’s role in the management of drug–drug interactions caused by nirmatrelvir/ritonavir in COVID-19 oncohematology patients. Journal of Oncology Pharmacy Practice, 31(3), 374–380. https://doi.org/10.1177/10781552241237750,
Hua, X. L., Gu, M., Zeng, F., Hu, H., Zhou, T., Zhang, Y., & Shi, C. (2020). Pharmacy administration and pharmaceutical care practice in a module hospital during the COVID-19 epidemic. Journal of the American Pharmacists Association, 60(3), 431-438.e1. https://doi.org/10.1016/J.JAPH.2020.04.006
Iftinan, G. N., Wathoni, N., & Lestari, K. (2021). Telepharmacy: A potential alternative approach for diabetic patients during the COVID-19 pandemic. Journal of Multidisciplinary Healthcare, 14, 2261–2273. https://doi.org/10.2147/JMDH.S325645,
Ji, G., Chen, C., Zhou, M., Wen, W., Wang, C., Tang, J., Cheng, Y., Wu, Q., Zhang, X., Wang, M., & Feng, Z. (2022). Post-COVID-19 fatigue among COVID-19 in patients discharged from hospital: A meta-analysis. Journal of Infection, 84(5), 722–746. https://doi.org/10.1016/J.JINF.2022.01.030
Kemenkes RI. (2023). Pemantauan COVID-19 Kementerian Kesehatan Republik Indonesia.
Kharaba, Z., Moutraji, S. A., Al Khawaldeh, R. A., Alfoteih, Y., & Al Meslamani, A. Z. (2022). What has changed in the pharmaceutical care after COVID-19: Pharmacists’ perspective. Pharmacy Practice, 20(2), 2656. https://doi.org/10.18549/PHARMPRACT.2022.2.2656
Li, H., Zheng, S., Liu, F., Liu, W., & Zhao, R. (2021). Fighting against COVID-19: Innovative strategies for clinical pharmacists. Research in Social and Administrative Pharmacy, 17(1), 1813–1818. https://doi.org/10.1016/J.SAPHARM.2020.04.003
Marjenberg, Z., Leng, S., Tascini, C., Garg, M., Misso, K., El Guerche Seblain, C., & Shaikh, N. (2023). Risk of long COVID main symptoms after SARS-CoV-2 infection: a systematic review and meta-analysis. Scientific Reports, 13(1). https://doi.org/10.1038/S41598-023-42321-9
Meakleartmongkol, T., Tangpanithandee, S., Vanavivit, N., Jiso, A., Pongchaikul, P., Kirdlarp, S., Khemawoot, P., & Nathisuwan, S. (2023). Potential drug–drug interactions of frequently prescribed medications in long COVID detected by two electronic databases. PLOS ONE, 18(11), e0293866. https://doi.org/10.1371/JOURNAL.PONE.0293866
Nasr, Z. G., Elamin, W., Basil, M., & Eljaaly, K. (2023). Pharmacist-driven antimicrobial stewardship interventions in patients with COVID-19: a scoping review. International Journal of Clinical Pharmacy, 45(3), 613–621. https://doi.org/10.1007/S11096-023-01574-0,
Poh, A. L., & Lin, W. (2021). Role of the pharmacist during the COVID-19 pandemic: a time to rethink strategies. Singapore Medical Journal, 62(6), 315. https://doi.org/10.11622/SMEDJ.2020098
Rahmati, M., Udeh, R., Yon, D. K., Lee, S. W., Dolja-Gore, X., McEVoy, M., Kenna, T., Jacob, L., López Sánchez, G. F., Koyanagi, A., Shin, J. Il, & Smith, L. (2023). A systematic review and meta-analysis of long-term sequelae of COVID-19 2-year after SARS-CoV-2 infection: A call to action for neurological, physical, and psychological sciences. Journal of Medical Virology, 95(6). https://doi.org/10.1002/JMV.28852,
Raman-Wilms, L. (2009). The Pharmacist as Patient Educator. The Canadian Journal of Hospital Pharmacy, 62(2), 93. https://doi.org/10.4212/CJHP.V62I2.436
Sarasmita, M. A., Sudarma, I. W., Adi Jaya, M. K., Irham, L. M., & Susanty, S. (2024). Telepharmacy Implementation to Support Pharmaceutical Care Services during the COVID-19 Pandemic: A Scoping Review. Canadian Journal of Hospital Pharmacy, 77(1). https://doi.org/10.4212/CJHP.3430,
Segal, E. M., Alwan, L., Pitney, C., Taketa, C., Indorf, A., Held, L., Lee, K. S., Son, M., Chi, M., Diamantides, E., & Gosser, R. (2020). Establishing clinical pharmacist telehealth services during the COVID-19 pandemic. American Journal of Health-System Pharmacy, 77(17), 1403–1408. https://doi.org/10.1093/AJHP/ZXAA184
SN, P., TM, H., & A, S. (2023). Pharmacist-Led Antimicrobial Stewardship and Antibiotic Use in Hospitalized Patients With COVID-19. Federal Practitioner : For the Health Care Professionals of the VA, DoD, and PHS, 40(6). https://doi.org/10.12788/FP.0380
Susanto, A. D., Isbaniah, F., Pratomo, I. P., Antariksa, B., Samoedro, E., Taufik, M., Harinda, F., & Nurwidya, F. (2022). Clinical characteristics and quality of life of persistent symptoms of COVID-19 syndrome in Indonesia. GERMS, 12(2), 158–168. https://doi.org/10.18683/GERMS.2022.1319,
Taner, N. (2023). Role of clinical pharmacists in post-COVID management. Acta Pharmaceutica Sciencia, 61(3). https://doi.org/10.1016/j.sapharm.2020.07.003
Tian, D.-S., Qin, C., Zhou, L., Hu, Z., Zhang, S., Yang, S., Tao, Y., Xie, C., Ma, K., Shang, K., Wang, W., & Tian, D.-S. (2020). Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China. Clinical Infectious Diseases, 71(15), 762–768. https://doi.org/10.1093/cid/ciaa248
Vos, T., Hanson, S. W., Abbafati, C., Aerts, J. G., Al-Aly, Z., Ashbaugh, C., Ballouz, T., Blyuss, O., Bobkova, P., Bonsel, G., Borzakova, S., Buonsenso, D., Butnaru, D., Carter, A., Chu, H., De Rose, C., Diab, M. M., Ekbom, E., Tantawi, M. El, … Murray, C. J. L. (2022). Estimated Global Proportions of Individuals with Persistent Fatigue, Cognitive, and Respiratory Symptom Clusters Following Symptomatic COVID-19 in 2020 and 2021. JAMA, 328(16), 1604–1615. https://doi.org/10.1001/JAMA.2022.18931,
Zheng, S. qian, Yang, L., Zhou, P. xiang, Li, H. bo, Liu, F., & Zhao, R. sheng. (2021). Recommendations and guidance for providing pharmaceutical care services during COVID-19 pandemic: A China perspective. Research in Social and Administrative Pharmacy, 17(1), 1819–1824. https://doi.org/10.1016/J.SAPHARM.2020.03.012
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